To delete users from Active Directory using AD Bulk Users add a column to your CSV/Excel/table named Delete along with the sAMAccountName (logon name) of each user, set the value in the Delete column to TRUE for each user to be deleted. If FALSE is found in the Delete column the user is ignored and not deleted.
If you want to delete the Home Folder or Profile Folder after deleting the user from AD then under PowerShell Scripts on the Settings ribbon you can set a script to run after the Delete process has finished, the script could delete the folders you need deleting.